Tetrahedron, Volume 74, Issue 15, 12 April 2018, Pages 1810-1816
“A practical method for heterogeneously-catalyzed Mizoroki-Heck reaction: Flow system with adjustment of microwave resonance as an energy source”
Tomohiro Ichikawa, Masahiro Mizuno, Shun Ueda, Noriyuki Ohneda, Hiromichi Odajima, Yoshinari Sawama, Yasunari Monguchi, Hironao Sajiki
The microwave-assisted and continuous-flow Mizoroki–Heck reaction using a heterogeneous palladium catalyst supported on the anion-exchange resin DIAION WA30 (7% Pd/WA30) is described. The microwave resonance is finely adjusted to 2.4 GHz according to the electric permittivity of the reaction medium for efficient heating. Organic solvents, such as acetonitrile, N,N-dimethylacetamide, and toluene, can be sufficiently heated even with a low intensity of microwave irradiation in a 7% Pd/WA30-packed, glass tube-shaped catalyst cartridge, which was designed based on the electric permittivity of the solvents. The catalyst cartridge can be continuously reused at least 5 runs without exchange.
実験結果提供：岐阜薬科大学 佐治木弘尚先生、第一薬科大学 門口泰也先生