溝呂木-Heck反応

反応結果

Tetrahedron, Volume 74, Issue 15, 12 April 2018, Pages 1810-1816
(https://doi.org/10.1016/j.tet.2018.02.044)

“A practical method for heterogeneously-catalyzed Mizoroki-Heck reaction: Flow system with adjustment of microwave resonance as an energy source”

Tomohiro Ichikawa, Masahiro Mizuno, Shun Ueda, Noriyuki Ohneda, Hiromichi Odajima, Yoshinari Sawama, Yasunari Monguchi, Hironao Sajiki

https://www.sciencedirect.com/science/article/pii/S0040402018301893

実験方法詳細

Abstract
  The microwave-assisted and continuous-flow Mizoroki–Heck reaction using a heterogeneous palladium catalyst supported on the anion-exchange resin DIAION WA30 (7% Pd/WA30) is described. The microwave resonance is finely adjusted to 2.4 GHz according to the electric permittivity of the reaction medium for efficient heating. Organic solvents, such as acetonitrile, N,N-dimethylacetamide, and toluene, can be sufficiently heated even with a low intensity of microwave irradiation in a 7% Pd/WA30-packed, glass tube-shaped catalyst cartridge, which was designed based on the electric permittivity of the solvents. The catalyst cartridge can be continuously reused at least 5 runs without exchange.

 

実験結果提供:岐阜薬科大学 佐治木弘尚先生、第一薬科大学 門口泰也先生

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